Protection against neurodegenerative diseases of Iris pseudopumila extracts and their constituents |
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| Authors: | Filomena Conforti Daniela Rigano Federica Menichini Monica Rosa Loizzo Felice Senatore |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, University of Calabria, I-87036 Rende (CS), Italy;2. Department of Chemistry of Natural Products, University of Naples “Federico II”, via D. Montesano 49-80131 Naples, Italy;3. Pharmacognosy Research Laboratories, Department of Pharmacy, King''s College London, Franklin-Wilkins Building, 150 Stamford St., London SE1, United Kingdom |
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| Abstract: | The present study describes for the first time the in vitro properties of Iris pseudopumila flowers and rhizomes extracts and their constituents. The methanolic extract of rhizomes showed significant anti-inflammatory activity through inhibition of NO production in the murine monocytic macrophage cell line RAW 264.7. Among the isolated compounds, those which most effectively inhibited LPS-induced NO production were irisolidone and 7-methyl-tectorigenin-4′-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside], with IC50 values of 23.6 μM and 29.4 μM respectively. Isoorientin and isovitexin exhibited the most promising activity against AChE with IC50 of 26.8 μM and 36.4 μM, respectively. The same compounds exhibited also the higher activity against BChE. |
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| Keywords: | Iris pseudopumila Tineo Iridaceae Phenolic compounds Anti-inflammatory activity Alzheimer's disease |
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