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Antitrypanosomal activity of polycarpol from Piptostigma preussi (Annonaceae) |
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| Authors: | Igor Ngantchou Ernestine Nkwengoua Yves Nganso Barthelemy Nyasse Colette Denier Veronique Hannaert Bernd Schneider |
| Institution: | 1. Laboratory of Bio-organic and Medicinal Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Box 812 Yaounde, Cameroon;2. UMR 5068, Groupe de Chimie Organique Biologique–LSPCMIB, Université Paul Sabatier, Bât II R1, 118 Route de Narbonne, 31062 Toulouse, Cedex 4, France;3. Unité de Recherche pour les Maladies Tropicales, Institut International des Pathologies Cellulaires & Moléculaires et Unité de Biochimie, Université de Louvain, Avenue Hippocrate 74–75, B-1200, Bruxelles, Belgium;4. Max Planck Institute for Chemical Ecology, Beutenberg Campus, Hans-Knöll-Str. 8, D-07745 Jena, Germany |
| Abstract: | Polycarpol, sitosterol and sitosterol-3-O-β-D-glucoside isolated for the first time from Piptostigma preussi (Annonaceae) occur regularly in some Annonaceae such as Piptostigma genus. Polycarpol exhibits interesting antitrypanosomal activity with an ED50 value of 5.11 µM on Trypanosoma brucei cells. Moreover, it inhibits T. brucei glycolytic enzymes GAPDH and PFK with IC50 values of 650 and 180 µM respectively. |
| Keywords: | Piptostigma preussi Chemotaxonomy Antitrypanosomal activity Trypanosoma brucei |
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