| 丹参壳聚糖眼用凝胶的制备及质量控制 |
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| 引用本文： | 赵亮,郭伟英,魏岚,刘蒙蒙. 丹参壳聚糖眼用凝胶的制备及质量控制[J]. 安徽农业科学, 2009, 37(10): 4369-4370 |
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| 作者姓名： | 赵亮 郭伟英 魏岚 刘蒙蒙 |
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| 作者单位： | 辽宁医学院药学院,辽宁锦州,121001;辽宁医学院药学院,辽宁锦州,121001;辽宁医学院药学院,辽宁锦州,121001;辽宁医学院药学院,辽宁锦州,121001 |
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| 摘 要： | [目的]制备丹参眼用凝胶,并建立其质量控制方法。[方法]采用脱乙酰度90%的壳聚糖为凝胶基质制备丹参壳聚糖眼用凝胶;采用紫外法（UV）测定制剂中丹参酮ⅡA的含量。[结果]丹参酮ⅡA在20-80μg/ml范围内呈良好的线性关系,Y=0.0879X＋0.0107（r=0.9994）。[结论]该法制备工艺简单,质量可控,有关项目符合眼用凝胶的质量要求。
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| 关 键 词： | 丹参 壳聚糖 眼用凝胶 制备 质量控制 |
Preparation and Quality Control of Salvia Miltiorrhiza Bge Chitosan Ophthalmic Gel |
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| ZHAO Liang et al. Preparation and Quality Control of Salvia Miltiorrhiza Bge Chitosan Ophthalmic Gel[J]. Journal of Anhui Agricultural Sciences, 2009, 37(10): 4369-4370 |
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| Authors: | ZHAO Liang et al |
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| Affiliation: | ZHAO Liang et al(Liaoning Medical University,Jinzhou,Liaoning 121001) |
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| Abstract: | [Objective] The study aims to prepare Salvia miltiorrhiza Bge ophthalmic gel and establish the method of quality control.[Method] 90% chitosan with deacetylation as matrix is used to make Salvia miltiorrhiza Bge ophthalmic gel,using UV method determines the contents of tanshinoneⅡA.[Result] The concentration of tanshinoneⅡA presents a good linear relation within the range of 20-80 μg/ml,Y=0.087 9X + 0.010 7,r =0.999 4.[Conclusion] This method is simple,the quality is able to control and some items accord with the quality need of ophthalmic gel. |
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| Keywords: | Salvia miltiorrhiza Chitosan Ophthalmic gel Preparation Quality control |
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