Composition, enantiomeric distribution, and antibacterial activity of the essential oil of Achillea ligustica All. from Corsica |
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Authors: | Filippi Jean-Jacques Lanfranchi Don-Antoine Prado Soizic Baldovini Nicolas Meierhenrich Uwe J |
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Institution: | LCMBA, UMR CNRS 6001, Université de Nice-Sophia Antipolis, Parc Valrose, F-06108 Nice Cedex 2, France. jfilippi@uni-hohenheim.de |
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Abstract: | The essential oil of Achillea ligustica from Corsica was investigated by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 82 compounds representing 94.0% of the oil were tentatively identified. The main constituents were the camphane derivatives, representing >30% (camphor, 21.3%; borneol, 6.2%; bornyl acetate, 3.5%) of the whole oil, and santolina alcohol (19.3%). The enantiomeric distribution of 8 chiral constituents was determined by GC-MS using two enantioselective stationary phases (DIME-beta-CD and Lipodex-E). Racemic santolina alcohol, required for optimization of the enantioselective GC conditions, was prepared by an original two-step synthesis from 2,5-dimethylhexa-2,4-diene. The whole essential oil was tested for its antibacterial activity against a wide range of bacteria using a paper disk method. The results show a promising activity against Streptomyces species. |
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