Monoterpenoid inhibitors of NO production from Paeonia suffruticosa |
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| Authors: | Liqin Ding Zhihu Jiang Yue Liu Lixia Chen Qian Zhao Xinsheng Yao Feng Zhao Feng Qiu |
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| Affiliation: | 1. Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, People''s Republic of China;2. Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, People''s Republic of China;3. School of Pharmacy, Yantai University, Laishan District, Yantai 264005, People''s Republic of China |
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| Abstract: | Three pairs of monoterpene glycosides (1–6), of which compounds 1, 3, and 4 as new compounds, together with one new monoterpene (7) were obtained from the ethanol extract of Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectral data. On this basis, the spectral characteristics of three pairs of monoterpene glycosides were also discussed. The inhibitory effects of isolated compounds on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated, and NO production was suppressed significantly by compounds 4–7. |
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| Keywords: | Paeonia suffruticosa Andrews Monoterpene glycosides Monoterpene Nitric oxide |
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