neo-Clerodane diterpenes from Ajuga decumbens and their inhibitory activities on LPS-induced NO production |
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| Authors: | Zhanping Sun Yushan Li Da-qing Jin Ping Guo Haibin Song Jing Xu Yuanqiang Guo Lei Zhang |
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| Institution: | 1. College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China;2. Shenyang Pharmaceutical University, Shenyang 110016, China;3. School of Medicine, Nankai University, Tianjin 300071, China;4. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | A phytochemical investigation of the whole plants of Ajuga decumbens led to the isolation of three new (1, 2a, and 2b) and three known (3a−3c) neo-clerodane diterpenes. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HR-ESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of the six diterpenes were evaluated and compounds 2a, 2b, and 3a showed inhibitory effects. |
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| Keywords: | Ajuga decumbens neo-Clerodane diterpenes Inhibitory activities on NO production |
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