Two pregnane derivatives and a quinolone alkaloid from Helicteres angustifolia |
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| Authors: | Guo-Cai Wang Tao Li Ying-Rou Wei Yan-Bo Zhang Yao-Lan Li Stephen Cho Wing Sze Wen-Cai Ye |
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| Institution: | 1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China;2. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, PR China;3. School of Chinese Medicine, LKS Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, PR China |
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| Abstract: | Phytochemical investigation of the ethanol extract from roots of Helicteres angustifolia led to the isolation of two new pregnane derivatives, heligenin A–B (1–2), and a new quinolone alkaloid, helicterone A (3), along with thirteen known compounds (4–16). The structures of new compounds were established by analysis of extensive spectroscopic data. The absolute configuration of 1 was determined by application of the modified Mosher's method. All of the isolates were evaluated for their anti-proliferative activities against HT-29 human colon cancer cells and OVCA 429 ovarian cancer cells by MTT assay. |
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| Keywords: | Helicteres angustifolia Sterculiaceae Pregnane derivatives Quinolone alkaloid Anti-proliferative activity |
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