Sesquiterpenes inhibiting NO production from Celastrus orbiculatus |
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| Authors: | Jing Xu Da-qing Jin Peng Zhao Xiaoqiang Song Zhanping Sun Yuanqiang Guo Lei Zhang |
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| Affiliation: | 1. College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China;2. School of Medicine, Nankai University, Tianjin 300071, China;3. Tianjin Children''s Hospital, Tianjin 300074, China |
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| Abstract: | Two new (1 and 2) and one known (3) β-dihydroagarofuran sesquiterpenes were isolated from the fruits of Celastrus orbicultus Thunb. Their structures were elucidated as 1β,13-diacetoxy-8β,9β-dibenzoyloxy-β-dihydroagarofuran (1), 1β,13-diacetoxy-8α-hydroxy-9β-benzoyloxy-β-dihydroagarofuran (2), and 1β,6α,13-triacetoxy-9α-benzoyloxy-β-dihydroagarofuran (3), on the basis of spectroscopic data analyses. All the compounds exhibited inhibitory effects on LPS-induced nitric oxide production in murine microglial BV-2 cells. |
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| Keywords: | Sesquiterpene Celastrus orbicultus Inhibitory effects of nitric oxide production |
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