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Prenylated phloroglucinol derivatives from Hypericum sampsonii |
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| Authors: | Wen-bo Xin Xiao-hua Man Cheng-jian Zheng Min Jia Yi-ping Jiang Xiang-xiang Zhao Gui-lin Jin Zhu-jun Mao Hai-qiu Huang Lu-ping Qin |
| Affiliation: | 1. Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China;2. Department of Gastroenterology, Changhai Hospital, Second Military Medical University, 174 Changhai Road, Shanghai 200433, PR China;3. Department of Pharmacology, Pharmacy College, Ningxia Medical University, 1160 Shengli Street, Yinchuan, Ningxia, 750004, PR China;4. Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA |
| Abstract: | Six new acylphloroglucinol derivatives, sampsonols A-F (1–6), were isolated from the petroleum ether extract of the aerial parts of Hypericum sampsonii. The structures and relative configurations of sampsonols A-F were elucidated by extensive spectroscopic analyses. All these compounds were tested for their in vitro cytotoxic and anti-inflammatory activities. Sampsonols A and B (1 and 2) showed significant cytotoxicity against four human tumor cell lines with IC50 values in the range of 13–28 μM, whereas sampsonols C and F (3 and 6) showed potent inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages with IC50 values of 27.3 and 29.3 μM, respectively. |
| Keywords: | Hypericum sampsonii Phloroglucinol Sampsonol Cytotoxicity Anti-inflammatory activity |
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