Antibacterial dihydrobenzopyran and xanthone derivatives from Garcinia cowa stem barks |
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| Authors: | Ittipon Siridechakorn Wong Phakhodee Thunwadee Ritthiwigrom Trinop Promgool Suwanna Deachathai Sarot Cheenpracha Uma Prawat Surat Laphookhieo |
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| Institution: | 1. Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand;2. Department of Chemistry, Faculty of Science, Chiang Mai University, Sutep, Muang, Chiang Mai 50200, Thailand;3. School of Science, University of Phayao, Maeka, Muang, Phayao 56000, Thailand;4. Department of Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Rassada, Muang, Phuket 83000, Thailand |
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| Abstract: | Two new compounds, garciniacowol (1) and garciniacowone (2) along with 15 known compounds were isolated from the stem barks of Garcinia cowa. Their structures were determined by intensive spectroscopic methods. The structure of 1 was a symmetrical dimeric dihydrobenzopyran derivative, whereas the framework of 2 was a triprenyl caged-xanthone precursor. The antibacterial activities against Escherichia coli TISTR 780, Salmonella typhimurium TISTR 292, Staphylococcus aureus TISTR 1466, and methicillin-resistant S. aureus (MRSA) SK1 of the isolated compounds were also evaluated. Compounds 2 and 9 exhibited good antibacterial activity against MRSA SK1 with the same minimum inhibitory concentration (MIC) value of 2 μg/mL. Moreover, compound 2 also showed good antibacterial activity against S. aureus with an MIC value of 2 μg/mL. |
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| Keywords: | Garcinia cowa Clusiaceae Dimeric chroman Rearranged triprenylxanthone Antibacterial activity |
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