BACE inhibitory flavanones from Balanophora involucrata Hook. f. |
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Authors: | Jiayi Tao Jun Zhao Ying Zhao Yanmei Cui Weishuo Fang |
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Affiliation: | 1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;2. Xinjiang Key Laboratory for Research and Development of Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi 830004, China;3. Key Laboratory for Cell Proliferation and Regulation Biology, Beijing Key Laboratory of Gene Engineering Drugs and Biological Technology, College of Life Sciences, Beijing Normal University, Beijing 100875, China |
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Abstract: | One new flavanone (S)-5,7,3′,5′-tetrahydroxy-flavanone-7-O-(6″-galloyl)-β-D-glucopyranose (1), together with one known flavanone and four known dihydrochalcones were isolated from the ethyl acetate partitions from an alcoholic extract of the whole plant of Balanophora involucrata Hook. f. All of the compounds were characterized by spectroscopic methods. Their in vitro BACE inhibitory effects were evaluated. Compounds 1, 2, 4, and 5 were found to be a little more active than the positive control, although all of which are below 50% inhibition at 10 μM. |
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Keywords: | Balanophora involucrata Hook. f. Flavanone BACE inhibition (S)-5,7,3&prime ,5&prime -tetrahydroxy-flavanone-7-O-(6&Prime -galloyl)-β-D-glucopyranose |
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