Lobarin from the Sumatran lichen, Stereocaulon halei |
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| Authors: | Friardi Ismed,Franç oise Lohé zic-Le Dé vé hat,Olivier Delalande,Sourisak Sinbandhit,Amri Bakhtiar,Joë l Boustie |
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| Affiliation: | 1. UMR CNRS 6226 ISCR, Equipe PNSCM, Faculté des Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, 35043 Rennes Cedex, France;2. UMR CNRS 6290 IGDR, Equipe SIM, Faculté des Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, 35043 Rennes Cedex, France;3. Centre Régional de Mesures Physiques de l''Ouest, Univ. Rennes 1, 35042 Rennes Cedex, France;4. Faculty of Pharmacy, Andalas University, 26163 Padang, Indonesia |
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| Abstract: | The diphenyl ether, lobarin (1) (syn. lobariol carboxylic acid) related to lobaric acid was isolated for the first time as a natural product along with five known compounds from Stereocaulon halei, a fruticose lichen collected in Indonesia. The structure of lobarin was elucidated by spectroscopic data analysis and its most stable conformers were determined by molecular mechanic dynamic calculations. A marked superoxide anion scavenging was found for compound 1 while no cytotoxicity on the B16 murine melanoma and HaCaT human keratinocyte cell lines was observed. |
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| Keywords: | SPF, Sun Protection Factor UVA-PF, UVA-Protection Factor MD, molecular dynamic RMSD, root mean square deviation. |
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