Comparison of time-action profiles of insulin Glargine and NPH insulin in normal and diabetic dogs |
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Authors: | A Mori T Sako P Lee T Motoike K Iwase Y Kanaya H Fukuta H Mizutani T Arai |
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Institution: | (1) Department of Veterinary Science, Nippon Veterinary and Life Science University, 1–7–1 Kyonancho, Musashino Tokyo, 180–8602, Japan;(2) Department of Veterinary Nursing, Nippon Veterinary and Life Science University, 1–7–1 Kyonancho, Musashino Tokyo, 180–8602, Japan |
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Abstract: | Intermediate insulin injections are commonly used for glycemic control in insulin dependent diabetic dogs acting as a replacement
for natural insulin. Neutral Protamin Hagedorn (NPH) insulin and insulin glargine are two types of injectable insulin preparations
commonly used in humans. In our study, we investigated the time-action profiles of both aforementioned insulin preparations
in normal dogs in order to determine whether co-administration of NPH and glargine would be of benefit to insulin dependent
diabetic dogs as it is for humans suffering from insulin dependent diabetes. Time-action profiles of NPH insulin and insulin
glargine in normal dogs demonstrated a clear difference between both insulin preparations confirming that NPH insulin is an
intermediate-acting preparation whereas insulin glargine is a long-lasting preparation. In addition, co-administration of
NPH insulin and insulin glargine resulted in tight glycemic control as compared to NPH insulin alone in insulin dependent
diabetic dogs. However, co-administration result in hypoglycemia at the dosages tested. |
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Keywords: | Diabetes Dog Insulin Glucose |
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