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Comparison of time-action profiles of insulin Glargine and NPH insulin in normal and diabetic dogs
Authors:A Mori  T Sako  P Lee  T Motoike  K Iwase  Y Kanaya  H Fukuta  H Mizutani  T Arai
Institution:(1) Department of Veterinary Science, Nippon Veterinary and Life Science University, 1–7–1 Kyonancho, Musashino Tokyo, 180–8602, Japan;(2) Department of Veterinary Nursing, Nippon Veterinary and Life Science University, 1–7–1 Kyonancho, Musashino Tokyo, 180–8602, Japan
Abstract:Intermediate insulin injections are commonly used for glycemic control in insulin dependent diabetic dogs acting as a replacement for natural insulin. Neutral Protamin Hagedorn (NPH) insulin and insulin glargine are two types of injectable insulin preparations commonly used in humans. In our study, we investigated the time-action profiles of both aforementioned insulin preparations in normal dogs in order to determine whether co-administration of NPH and glargine would be of benefit to insulin dependent diabetic dogs as it is for humans suffering from insulin dependent diabetes. Time-action profiles of NPH insulin and insulin glargine in normal dogs demonstrated a clear difference between both insulin preparations confirming that NPH insulin is an intermediate-acting preparation whereas insulin glargine is a long-lasting preparation. In addition, co-administration of NPH insulin and insulin glargine resulted in tight glycemic control as compared to NPH insulin alone in insulin dependent diabetic dogs. However, co-administration result in hypoglycemia at the dosages tested.
Keywords:Diabetes  Dog  Insulin  Glucose
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