Histogenesis of neoformation in the endocrine pancreas of aging horses |
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| Authors: | H Furuoka T Shirakawa H Taniyama H Ohishi H Satoh C Itakura |
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| Affiliation: | Department of Comparative Pathology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan. |
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| Abstract: | Pancreatic tissue from 20 horses was examined using immunocytochemical techniques. In aged horses, neogenesis of endocrine cells, neoformation, and hyperplasia of islets occurred closely associated with the pancreatic duct; these changes were regarded as nesidioblastosis. In addition, pancreatic fibrosis accompanied by ductal proliferation and endocrine neogenesis was considered a regenerative change. Thus, the origin of neoformation in the endocrine pancreas was in the ductal system, and it is suggested that the pancreatic endocrine cells were of endodermal origin. |
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