Antibiotic stress induces genetic transformability in the human pathogen Streptococcus pneumoniae |
| |
Authors: | Prudhomme Marc Attaiech Laetitia Sanchez Guillaume Martin Bernard Claverys Jean-Pierre |
| |
Institution: | Laboratoire de Microbiologie et Génétique Moléculaires, UMR 5100 CNRS-Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France. |
| |
Abstract: | Natural transformation is a widespread mechanism for genetic exchange in bacteria. Aminoglycoside and fluoroquinolone antibiotics, as well as mitomycin C, a DNA-damaging agent, induced transformation in Streptococcus pneumoniae. This induction required an intact competence regulatory cascade. Furthermore, mitomycin C induction of recA was strictly dependent on the development of competence. In response to antibiotic stress, S. pneumoniae, which lacks an SOS-like system, exhibited genetic transformation. The design of antibiotherapy should take into consideration this potential of a major human pathogen to increase its rate of genetic exchange in response to antibiotics. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|