Platelet-rich Plasma Combined With a Sterile 3D Polylactic Acid Scaffold for Postoperative Management of Complete Hoof Wall Resection for Keratoma in Four Horses |
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| Affiliation: | 1. Department of Veterinary Science, University of Parma, Parma, Italy;2. Department of Veterinary Science, University of Messina, Messina, Italy;1. Programa de Pós-Graduação em Ciência Animal nos Trópicos, Universidade Federal da Bahia (UFBA), Salvador-BA, Brazil;2. Escola de Medicina Veterinária e Zootecnia (ESCMEV), Universidade Federal da Bahia (UFBA), Salvador-BA, Brazil;3. Núcleo de Pesquisa Equina, Universidade Federal Rural de Pernambuco (UFRPE), Recife-PE, Brazil;4. Department of Veterinary Sciences, University of Messina, Messina, Italy;1. Department of Agrarian Studies, Universidade Regional do Noroeste do Estado do Rio Grande do Sul, Ijuí, Rio Grande do Sul, Brazil;2. Postgraduate Program in Animal Medicine: Equine, College of Veterinary Medicine Federal University of Rio Grande do Sul – UFRGS. Av. Bento Gonçalves, Porto Alegre, Rio Grande do Sul, Brazil;3. College of Veterinary Medicine, Federal University of Rio Grande do Sul – UFRGS, Porto Alegre, Rio Grande do Sul, Brazil;4. Department of Large Animal Medicine, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil;1. Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, RS;2. Master’s Student at Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, RS;3. Researcher Teacher at Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, RS;4. Researcher Teacher at Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, RS;5. Master’s Student at Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, RS;1. School of Veterinary Medicine - Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil;2. Department of Pathology, School of Medicine, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil;3. Department of Chemistry and Biological Sciences, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil |
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| Abstract: | Keratoma is a nonmalignant horse tumor that grows in the space between the horn of the hoof and the distal phalanx. Keratoma causes lameness in the horse, and surgical excision is the treatment of choice. Four horses underwent removal of a keratoma by complete hoof wall resection. The remaining wound was treated with platelet-rich plasma (PRP) combined with a sterile three-dimensional polylactic acid scaffold. The PRP was applied at 3, 6, 9, 12, 15, and 18 days postoperatively. The surgical site was cleaned with gauzes and swabs soaked in Ringer’s lactate solution before applying PRP and the foot bandage. Healthy granulation tissue developed at 6–21 days postoperatively. The hoof wall defect was completely filled with new hoof wall within 6–8 months after surgery. All horses returned to their previous exercise level, and no recurrence of lameness was reported by the owner. |
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| Keywords: | Platelet-rich plasma PRP Regenerative medicine therapy Keratoma Horse |
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