Effects of the Glucosinolate Sinigrin in Combination With a Noniodine Supplemented Diet on Serum Iodine and Thyroid Hormone Concentrations in Nonpregnant Mares |
| |
| Institution: | 1. Department Large Animal Clinical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;2. Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;3. Department of Veterinary Pathology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;1. School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia;2. South Australian Research and Development Institute, Turretfield Research Centre, Rosedale, South Australia, Australia;1. Racehorse Hospital, Miho Training Center, Japan Racing Association, Ibaraki, Japan;2. Laboratory of Racing Chemistry, Utsunomiya, Tochigi, Japan;3. Racehorse Hospital, Ritto Training Center, Japan Racing Association, Shiga, Japan;4. Equine Department, Japan Racing Association, Tokyo, Japan;1. Programa de Pós-Graduação em Ciência Animal nos Trópicos, Universidade Federal da Bahia (UFBA), Salvador-BA, Brazil;2. Escola de Medicina Veterinária e Zootecnia (ESCMEV), Universidade Federal da Bahia (UFBA), Salvador-BA, Brazil;3. Núcleo de Pesquisa Equina, Universidade Federal Rural de Pernambuco (UFRPE), Recife-PE, Brazil;4. Department of Veterinary Sciences, University of Messina, Messina, Italy;1. Department of Veterinary Medicine, Animal Reproduction, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, Brazil;2. Department of Veterinary Medicine, Surgery and Anaesthesiology, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, Brazil;3. Department of Veterinary Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Brazil;4. Department of Veterinary Medicine, Clinic of Large Animals, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, Brazil;1. Equine Sciences, Colorado State University, Fort Collins, CO;2. Cooperative Research Farms, Richmond, VA;1. College of Health Science, School of Veterinary Medicine, Wollega University, Nekemte, Ethiopia;2. Department of Veterinary Medicine, College of Food and Agriculture, United Arab Emirates University, Al Ain, United Arab Emirates;3. Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia;4. Department of Clinical Studies, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia |
| |
| Abstract: | Exposure to plants containing glucosinolates (GSLs) affects thyroid function in many species, in horses is implicated in the birth of foals with congenital hypothyroidism. The present study was performed to determine the effect of feeding a GSL (sinigrin) in combination with a low-iodine diet for 12 weeks on thyroid hormones and serum iodine concentrations in nonpregnant mares. Nineteen mares aged 2–14 years were divided into control (n = 6), low (20 mmol/day) (n = 7) and high GSL (35 mmol/day) (n = 6) groups. Thyrotropin-releasing hormone (TRH) stimulation tests and serum iodine measurements were performed at 0 and 12 weeks. Total triiodothyronine (TT3), total thyroxine (TT4), and thyroid-stimulating hormone (TSH) concentrations were measured at the baseline and in post-TRH samples. The post-TRH value minus the basal value (Delta Δ) and fold change (FC) were calculated for TSH, TT3, and TT4. Data were analyzed at P < .05. Highlights included Delta Δ and FC TT4 and TT3 concentrations having a group and week interaction (P < .001) with week 12 control mares having higher values than mares in week 12 low and high GSL groups. TT4 FC values had a group (P < .001) and group by week interaction (P < .001) with week 12 control concentrations higher (P < .006) than all groups. Iodine concentrations decreased (P < .002) over time in GSL mares. In conclusion, feeding mares a low-iodine diet with 20 and 35 mmol sinigrin/day resulted in lower serum iodine concentrations. |
| |
| Keywords: | Mare Iodine Glucosinolate Sinigrin Thyroid hormones |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
