Investigation of the Usefulness of Serum Amyloid A in Supporting the Diagnosis of Equine Proliferative Enteropathy |
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| Affiliation: | 1. Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA;2. Zoetis, Parsippany, NJ;3. Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Minnesota, St. Paul, MN;1. Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel;2. Department of Bacteriology and Mycology, The Kimron Veterinary Institute, Bet Dagan, Israel;3. Department of Geography and Environment, Bar-Ilan University, Ramat-Gan, Israel;4. Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, KY;1. Department of Veterinary Science, Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, KY;2. Hawk Wing, Tipperary, Ireland;3. Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY;1. Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Kentucky, USA;2. Department of Clinical Sciences, Auburn University, Auburn, Alabama, USA;3. Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, USA;4. Theriogenology Department, Faculty of Veterinary Medicine, University of Mansoura, Egypt;5. Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, Brazil;6. Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium;7. Division of Comparative Pathology, University of Miami Miller School of Medicine, Miami, USA |
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| Abstract: | The objective of this study was to determine if serum amyloid A (SAA), a major acute-phase protein, could help support the diagnosis of equine proliferative enteropathy (EPE) caused by Lawsonia intracellularis infection in foals. Archived serum samples from 101 foals with enteric signs and hypoproteinemia were available for SAA testing. Based on immunodiagnostics for L. intracellularis, the foals were divided into EPE-suspect (67) and non–EPE-suspect cases (34). Serum amyloid A values ranged from 0 to 2,761 μg/mL (median 466 μg/mL) and from 0 to 2,555 μg/mL (median 192 μg/mL) for the EPE-suspect and the non–EPE-suspect cases, respectively. Although SAA can be measured patient-side and help determine the severity of the underlying inflammatory condition, SAA was unable to consistently support the diagnosis of EPE in hypoproteinemic foals with enteric signs. |
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| Keywords: | Equine proliferative enteropathy Foal Serum amyloid A Testing |
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