Hormonal Stimulation in a Gonadal Dysgenesis Mare |
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| Institution: | 1. REPROLAB – Faculdade de Veterinária, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil;2. B.E.T. Laboratories, Lexington, KY;1. Animal Science Department, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil;2. Animal Science Department, Federal University of Lavras, Lavras, Minas Gerais, Brazil;3. Veterinary Department, Federal University of Lavras, Lavras, Minas Gerais, Brazil;4. Animal Reproduction Department, College of Veterinary and Animal Science, University of Sao Paulo, São Paulo, SP, Brazil;1. Escuela de Medicina Veterinaria, Facultad de Recursos Naturales y Medicina Veterinaria, Universidad Santo Tomás, Chile;2. Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile;3. Facultad de Ciencias Agronómicas, Universidad de Chile, Santiago, Chile;1. Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran;2. Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran;1. Pferdezentrum Bad Saarow, Freie Universität Berlin, Bad Saarow, Germany;2. Klinik für Reproduktionsmedizin und Zentrum für Klinische Studien, Vetsuisse Fakultät Zürich, Universität Zürich, Lindau, Switzerland;3. Institut für Genetik, Vetsuisse Fakultät Bern, Universität Bern, Bern, Switzerland;1. Northern Ireland Public Health Laboratory, Nightingale (Belfast City) Hospital, Belfast, Northern Ireland, UK;2. School of Medicine, Dentistry and Biomedical Science, The Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University, Belfast, Northern Ireland, UK |
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| Abstract: | The present case report aimed to determine the responsiveness of the endometrium and the ovaries of an X0 mare after hormonal treatment. On transrectal palpation, the uterus was flaccid and smaller than normal, and the ovaries were small and smooth. The endometrium had normal histological architecture, with an atrophic glandular epithelium. A karyotype evaluation was performed, and 70 cells presented 63 chromosomes, lacking one sex chromosome. Circulating hormonal levels of total estrogens were 43.93 pg/mL; progesterone 0.01 ng/mL; testosterone 48 pg/mL; FSH 30.3 ng/mL; and LH 1.71 ng/mL. Immunohistochemistry tests showed the presence of estrogens and progesterone receptors in the endometrial samples of the X0 mare. 17β estradiol was administrated on three consecutive days and long-action progesterone on the fourth day. After hormonal stimulation, the mare showed changes in endometrial ultrasonography and histology. After treatment with estradiol, uterine edema was noted, and after progesterone, a reduction in edema was observed. At the request of the owner, no further treatment or follow-up occurred. This report showed that the endometrium is functional, but the ovaries did not change macroscopically under hormonal therapy. |
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| Keywords: | Horse Reproductive failure X0 Sexual hormones Acyclic mare |
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