Ochracenoids A and B,Guaiazulene-Based Analogues from Gorgonian Anthogorgia ochracea Collected from the South China Sea |
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| Authors: | Juan-Juan Zheng Chang-Lun Shao Min Chen Li-She Gan Yu-Chun Fang Xu-Hui Wang Chang-Yun Wang |
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| Institution: | 1.Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; E-Mails: (J.-J.Z.); (C.-L.S.); (M.C.); (Y.-C.F.); (X.-H.W.);2.Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; E-Mail: |
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| Abstract: | Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3–6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration of 1 was determined as 3R by the comparison of TDDFT calculated electronic circular dichroism with its experimental spectrum. Compound 1 is a rare guaiazulene-based analogue possessing a unique C16 skeleton. The possible generation process of 1 through an intermolecular one-carbon-transfer reaction was also discussed. Compound 2 was previously described as a presumed intermediate involved in the biogenesis of anthogorgienes A and I. Compound 3 exhibited antiproliferative effects on the embryo development of zebrafish Danio rerio. |
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| Keywords: | gorgonian Anthogorgia ochracea guaiazulene-based analogue antiproliferative effect zebrafish embryo |
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