| 装置影响昆明小鼠物体再认记忆 |
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| 引用本文： | 王超,江伟,黄德武,陶飞,陈贵海. 装置影响昆明小鼠物体再认记忆[J]. 安徽农业大学学报, 2009, 36(2) |
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| 作者姓名： | 王超 江伟 黄德武 陶飞 陈贵海 |
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| 作者单位： | 安徽医科大学第一附属医院神经内科,合肥,230022;安徽医科大学实验动物中心,合肥,230032 |
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| 基金项目： | 国家自然科学基金，安徽省高校省级自然科学研究重大项目 |
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| 摘 要： | 在3种试验装置(Y形、方形及矩形)中检测昆明小鼠新物体再认能力的年龄及性别效应.结果表明,10 min延迟试验中3个装置都没有检测到年龄和性别差异;24 h延迟试验中21月龄鼠较6月龄和12月龄鼠新物体再认能力下降,且主要归因于雌鼠,Y形装置检测的数据较其他2个装置更敏感和稳定.以上结果提示,老年昆明雌鼠有遥远新物体再认记忆减退,Y形装置最敏感.
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| 关 键 词： | 衰老 行为 记忆 小鼠 |
Effects of apparatus on age-related impairement of novel-object recognition in Kunming mice |
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| WANG Chao,JIANG Wei,HUANG De-wu,TAO Fei,CHEN Gui-hai. Effects of apparatus on age-related impairement of novel-object recognition in Kunming mice[J]. Journal of Anhui Agricultural University, 2009, 36(2) |
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| Authors: | WANG Chao JIANG Wei HUANG De-wu TAO Fei CHEN Gui-hai |
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| Affiliation: | 1.Department of Neurology;the Affiliated Hospital of Anhui Medical University;Hefei 230022;2.Experimental Animal Center;Anhui Medical University;Hefei 230032 |
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| Abstract: | The effects of different apparatus,i.e.,Y-shape,square and rectangle boxs,on age-related impairement of memory in novel-object recognition task in Kunming mice were explored,respectively.The results indicated that there were no age-related changes in the 10-minute-delay trial in each of apparatus.During the 24 hours delay trial,the ability of novel-object recognition in the 21-month mice decreased in the Y-shape box compared to the 6-month and 12-month mice,and in the square box compared to the 12-month mic... |
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| Keywords: | aging behavior memory mouse |
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