儿茶素的药理作用研究综述

随着社会的发展和人们保健意识的加强，对于有诸多活性的植物黄酮的关注度越来越高，表儿茶素作为拥有类黄酮结构的儿茶素类化合物，是植物、食品和中药材中的重要活性成分之一，广泛存在于茶叶、可可、药材中，在茶叶中约占儿茶素的5%~7%。黄烷醇结构使其具有诸多黄酮的药理活性，现代医药学表明：表儿茶素具有抗氧化、降脂降糖、抑制胰岛素抵抗、防止心血管疾病、抗炎、抑菌、提高免疫力等生理活性，这些活性被认为由表儿茶素的多羟基结构的分子结构特性导致。本文拟对表儿茶素的天然植物来源、结构解析和多种药理活性等进行综述，并对中国天然植物来源的表儿茶素的开发应用前景提供建议，为今后该化合物的开发和研究提供理论借鉴。

Use of thiolysis hyphenated to RP-HPLC-ESI(-)-MS/MS for the analysis of flavanoids in fresh lager beers

With the development of society and growing of people’s health care awareness, the activities of many plant flavonoids have been paid more and more attention. Epicatechin, which possesses the flavonoid structure of catechin compound, is one of the important bioactive components as well as widely found in tea, cocoa, herbs, its content in tea could be approximately up to 5%-7% of catechins. Because of its basic flavanol structure, it has many pharmacological activities of flavonoids, many modern medicine researches have revealed that epicatechin owns many physiological activities such as antioxidant, hypoglycemic, hypoglycemic, insulin resistance, as well as preventing cardiovascular disease, anti-inflammatory, antibacterial, enhancing immunity, and so on. The epicatechin polyhydroxy structure would be contributed to these bioactivities. In this paper, the natural sources, structural analysis and multi-pharmacological activities of epicatechin were reviewed, meanwhile, the development and application prospect of epicatechin from natural plant sources in nation were proposed, which would provide theoretical reference for the development and research of this compound in the future.