香豆素类化合物对朱砂叶螨的触杀活性及定量构效关系研究

香豆素类化合物是自然界广泛存在的一类具有苯并α-吡喃酮结构的天然化合物，具有抗癌、抗菌、抗炎和抗氧化等生理活性，同时也具有良好的杀虫、杀菌等农用活性。近年来研究表明，香豆素类化合物的杀螨活性更为突出，而且具有独特的作用靶标，具有开发成新型杀螨剂的潜力。本文综述了香豆素类化合物及其衍生物的杀虫、杀螨和抑菌活性，重点介绍了具有杀螨活性的香豆素类化合物的结构修饰、构效关系以及东莨菪内酯等对朱砂叶螨Tetranychus cinnabarinus的作用机制，明确其杀螨活性的主要作用靶标是新型的钙离子通道相关的G蛋白偶联神经肽受体 (TcGPCR)。这些研究进展为以香豆素类化合物为模板、以钙离子通道为靶标的新型植物性杀虫、杀螨剂的创制提供了重要基础。

Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential

Coumarin derivatives are a class of natural compounds with phenylhydrazine α-pyrone structure. They exhibit a broad scope of medical (e.g., anticancer, antibacterial, antiinflammatory and antioxidant activities) and pesticidal activities (e.g., insecticidal and antifungal activities). Recent studies have shown that coumarin compounds have the potential to become novel acaricides because of their prominent acaricidal activities and unique target. In this review, the advances on insecticidal, acaricidal, antibacterial activities of coumarin derivatives have been summarized. The structural modification and structure-activity relationship of coumarin derivatives and the acaricidal mechanism of scopoletin against Tetranychus cinnabarinus have also been reviewed. The main target has been identified as the calcium channel-associated G-protein coupled neuropeptide receptor (TcGPCR). These advances provide an important basis for the development of new phytochemical insecticidal and acaricidal agents derived from coumarin and targeting calcium ion channels.