Immunomodulatory Properties of Highly Viscous Polysaccharide Extract from the Gagome Alga (<Emphasis Type="Italic">Kjellmaniella crassifolia</Emphasis>) |
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Authors: | Shigeru Katayama Toshihiro Nishio Hideki Kishimura Hiroki Saeki |
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Institution: | (1) Faculty of Fisheries Sciences, Hokkaido University, Hakodate Minato 3-1-1, Hokkaido 041-8611, Japan;(2) Present address: Faculty of Agriculture, Shinshu University, Minamiminowa, Nagano 399-4598, Japan; |
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Abstract: | Marine brown algae are rich in sulfated polysaccharides, which have the ability to form gels and viscous solution. Sulfated
polysaccharides exhibit many biological activities; however, little is known whether the viscoelastic property in the polysaccharide
extract is correlated with biological activities. We examined the immunomodulatory properties of highly viscous polysaccharide
extract (HVPE) from Gagome Kjellmaniella crassifolia in a murine model, and the effects were compared with those of a less viscous polysaccharide extract (LVPE). HVPE or LVPE
(10, 30, and 100 mg/kg/day) were orally administered to C57BL/6 mice for 14 days. Secretions of cytokine and IgA in Con A-stimulated
spleen and Peyer’s patch (PP) cells and phagocytic activity of peritoneal macrophages was determined. IFN-γ, IL-12, IL-6,
and IgA secretions showed high levels in spleen cell cultures from mice administered HVPE, whereas these effects were diminished
in the LVPE-administered mice. The phagocytic activity of peritoneal macrophages was enhanced by the continuous oral administration
of HVPE, and these effects were higher than those of LVPE. Furthermore, an increase in IgA secretion by administration of
HVPE was observed in Con A-stimulated PP cells. These results suggest that the polysaccharide extract from K. crassifolia has immunomodulatory activities, which depend on the viscosity. |
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