| 石杉碱甲的分离检测方法及主体植物源的研究进展 |
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| 引用本文： | 高思青,禹利君.石杉碱甲的分离检测方法及主体植物源的研究进展[J].湖南农业大学学报(自然科学版),2009,35(Z1). |
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| 作者姓名： | 高思青 禹利君 |
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| 作者单位： | 湖南农业大学,茶学教育部重点实验室;湖南省天然产物研究中心,长沙,410128 |
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| 基金项目： | 湖南省自然科学基金项目，湖南省教育厅项目 |
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| 摘 要： | 石杉碱甲是从石杉科植物蛇足石杉中提取的一种石松生物碱,是一种高效乙酰胆碱酯酶抑制剂,主要用来治疗老年性痴呆症(Alzheimer disease,AD)、重肌无力、增强学习记忆、改善空间记忆障碍等疾病.主要对石杉碱甲的分离检测方法、石杉碱甲源主体植物、石杉碱甲的微生物新来源等方面进行综述,提出发掘、利用石杉碱甲新资源,以解决目前石杉科植物中石杉碱甲含量低、用药需求受到限制的难题.
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| 关 键 词： | 石杉碱甲 分离检测方法 主体植物源 微生物新资源 |
Reviews of separation and determination of Huperzine A and its main plant sources |
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| Abstract: | Huperzine A is one of Lycopidium alkaloids isolated from Huperziaceae plants-Huperzia serrata (Thunb) Thev. It's a potent and reversible inhibitor of acetylcholinesterase and has marked pharmacological effects. It could be used for curing Alzheimer disease, antagonize muscular relaxation, enhancing learning effectiveness and preventiving the memory dysfunction, improving spacial anamnesis obstacle, and so on. This paper mainly summarized separation and detection methods, dominating plant sources, novel microorganism sources of Huperzine A. Therefor, we put forward to exploit Huperzine A novel sources for resolving clinical medicine restricted and low content in huperziaceae plants. |
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| Keywords: | Huperzine A separation and detection methods dominating plant sources novel microorganism sources |
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