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| Caffeoyl Glycoside对脾淋巴细胞生长周期及膜表面标志的影响 | |
| 引用本文： | 曹永国,邓旭明,张乃生,刘佳丽,刘育华,谢光洪,许超,吴殿君,周昌芳.Caffeoyl Glycoside对脾淋巴细胞生长周期及膜表面标志的影响[J].甘肃农业大学学报,2009,44(4). |
| 作者姓名： | 曹永国 邓旭明 张乃生 刘佳丽 刘育华 谢光洪 许超 吴殿君 周昌芳 |
| 作者单位： | 1. 吉林大学畜牧兽医学院,吉林,长春130062 2. 吉林农业大学动物科学技术学院,吉林,长春130118 3. 宁波市镇海区畜牧兽医总站,浙江,宁波315200 |
| 摘 要： | 用流式细胞术测定了从西藏胡黄连分离的Caffeoyl Glycoside(CG)对小鼠脾淋巴细胞生长周期及其膜表面标志CD4+、CD8+的影响.结果表明:CG通过促进脾淋巴细胞G0/G1期向DNA合成期(S期)转化,从而促进脾淋巴细胞增殖,对脾淋巴细胞膜表面标志的影响,是通过CG上调CD4+、CD8+和CD4+CD8+双阳性细胞亚群,即主要是通过提高Th细胞的数量发挥免疫增强作用. |
| 关 键 词： | Caffeoyl Glycoside 脾淋巴细胞 流式细胞术 S期 CD4+/CD8+ 免疫增强 |
Effects of Caffeoyl Glycoside on the cellular membrane surface marker and cell cycle of spleen lymphocyte |
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| CAO Yong-guo,DENG Xu-ming,ZHANG Nai-sheng,LIU Jia-li,LIU Yu-hua,XIE Guang-hong,XU Chao,WU Dian-jun,ZHOU Chang-fang.Effects of Caffeoyl Glycoside on the cellular membrane surface marker and cell cycle of spleen lymphocyte[J].Journal of Gansu Agricultural University,2009,44(4). | |
| Authors: | CAO Yong-guo DENG Xu-ming ZHANG Nai-sheng LIU Jia-li LIU Yu-hua XIE Guang-hong XU Chao WU Dian-jun ZHOU Chang-fang |
| Institution: | CAO Yong-guo1,DENG Xu-ming1,ZHANG Nai-sheng1,LIU Jia-li2,LIU Yu-hua3,XIE Guang-hong1,XU Chao1,WU Dian-jun1,ZHOU Chang-fang1(1.College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062,China,2.College of Animal Science and Technology,Jilin Agricultural University,Changchun 130118,3.Animal Husbandry and Veterinary Central Station of Zhenhai District of Ningbo City,Ningbo 315200,China) |
| Abstract: | The pre-clinical trial has successfully isolated a monomer named Caffeoyl Glycoside(CG) from the roots of Picrorrhiza kurroa.The current initial study indicated that CG could promote the major immunocyte proliferation and other immune function in mice in vitro,and had immunoenhancement effects.To further verify the molecule mechanism of CG on mice spleen lymphocyte,we analyzed spleen lymphocyte cell cycle and cellular membrane surface marker CD4+,CD8+ after CG stimulation by flow cytometry.The results showe... |
| Keywords: | Caffeoyl Glycoside CD4+/CD8+ |
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