Phylogenetic analysis and characterization of Korean bovine viral diarrhea viruses |
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Authors: | Jae-Ku Oem Bang-Hun Hyun Sang-Ho Cha Kyoung-Ki Lee Seong-Hee Kim Hye-Ryoung Kim Choi-Kyu Park Yi-Seok Joo |
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Institution: | aAnimal Disease Diagnostic Center, National Veterinary Research and Quarantine Service, Gyeonggi-do, 430-824, Republic of Korea |
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Abstract: | Thirty-six bovine viral disease viruses (BVDVs) were identified in bovine feces (n = 16), brains (n = 2), and aborted fetuses (n = 18) in Korea. To reveal the genetic diversity and characteristics of these Korean strains, the sequences of their 5′-untranslated regions (5′-UTRs) were determined and then compared with published reference sequences. Neighbor-joining phylogenetic analysis revealed that most of the Korean viruses were of the BVDV subtypes 1a (n = 17) or 2a (n = 17). The remaining strains were of subtypes 1b (n = 1) and 1n (n = 1). This analysis indicates that the 1a and 2a BVDV subtypes are predominant and widespread in Korea. In addition, the prevalence of BVDV-2 was markedly higher in aborted fetuses than in other samples and was more often associated with reproductive problems and significant mortality in cattle. |
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Keywords: | BVDV-1 BVDV-2 Phylogenetic analysis Korea |
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