| Zonarol类天然混源萜的合成及其生物活性研究进展 |
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| 引用本文： | 孙盛鑫, 王侠, 李圣坤. Zonarol类天然混源萜的合成及其生物活性研究进展[J]. 农药学学报, 2023, 25(3): 485-499. DOI: 10.16801/j.issn.1008-7303.2023.0005 |
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| 作者姓名： | 孙盛鑫 王侠 李圣坤 |
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| 作者单位： | 1.贵州大学 绿色农药与农业生物工程国家重点实验室培育基地/教育部重点实验室，贵阳 550025;2.南京农业大学 植物保护学院，南京 210095 |
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| 基金项目： | 国家自然科学基金(21977049)； |
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| 摘 要： | 天然产物是药物先导研发的重要资源。基于混合生源途径的drimane 醌/氢醌类天然产物因独特的结构和多样的生物活性而引起化学家和生物学家的广泛兴趣。这类天然产物由drimane或重排的drimane与醌或氢醌通过C(sp2)-C(sp3)链接，其中代表性的天然产物zonarol在分离之初被报道具有抗真菌活性，随后被证明具有拒食活性、抗肿瘤活性、抗炎活性和杀藻活性，具有较好的药物先导开发潜力。本文介绍了zonarol及其类似物的合成、结构优化及生物活性，可为合成结构多样的drimane醌/氢醌类化合物以及进一步的药理研究奠定基础，对农药先导创新具有有益的启发作用。
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| 关 键 词： | drimane 醌/氢醌 zonarol 全合成 生物活性 |
| 收稿时间： | 2022-11-19 |
Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019 |
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| SUN Shengxin, WANG Xia, LI Shengkun. Advances in the synthesis and bioactivities of zonarol-related natural products[J]. Chinese Journal of Pesticide Science, 2023, 25(3): 485-499. DOI: 10.16801/j.issn.1008-7303.2023.0005 |
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| Authors: | SUN Shengxin WANG Xia LI Shengkun |
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| Affiliation: | 1.Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China;2.College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China |
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| Abstract: | Natural products are an important resource for pharmaceutical development. From the mixed biogenesis of polyketide-terpenoid origin, drimane quinones/hydroquinones have attracted widespread attention by chemists and biologists for their unique structures and diverse biological activities. This class of natural products were made up of drimane or rearranged drimane connected with quinone or hydroquinone via C(sp2)-C(sp3) linker. Zonarol was isolated as a typical drimane meroterpenoid with antifungal activity. It was later demonstrated to have anti-feeding activity, antitumor activity, anti-inflammatory activity, algicidal activity, which have good potential for the discovery of novel pharmaceutical leads. The advances in the synthesis, structure optimization and biological activity of zonarol and its analogues were showcased, aiming for the practical optimization and pharmacological studies. This may serve as a useful inspiration for the discovery of new agrochemicals. |
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| Keywords: | drimane quinone/hydroquinones zonarol total synthesis bioactivity |
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