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A whole-genome association study of major determinants for host control of HIV-1 |
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| Authors: | Fellay Jacques Shianna Kevin V Ge Dongliang Colombo Sara Ledergerber Bruno Weale Mike Zhang Kunlin Gumbs Curtis Castagna Antonella Cossarizza Andrea Cozzi-Lepri Alessandro De Luca Andrea Easterbrook Philippa Francioli Patrick Mallal Simon Martinez-Picado Javier Miro José M Obel Niels Smith Jason P Wyniger Josiane Descombes Patrick Antonarakis Stylianos E Letvin Norman L McMichael Andrew J Haynes Barton F Telenti Amalio Goldstein David B |
| Affiliation: | Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA. |
| Abstract: | Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents. |
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