Development and characterization of multifunctional electrospun ferric oxide-gelatin-glycerol nanofibrous mat for wound dressing applications |
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Authors: | R Morsy M Hosny F Reicha T Elnimr |
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Institution: | 1.Biophysics Laboratory, Physics Department, Faculty of Science,Tanta University,Tanta,Egypt;2.Physics Department, Faculty of Science,Mansoura University,Mansoura,Egypt |
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Abstract: | In this study, we developed optimal multifunctional electrospun wound dressings possessing an antibacterial activity and rich in iron, a vital trace element for cell growth. Therefore, synthetic ferric oxide nanoparticles (α-Fe2O3 NPs) were ultrasonically dispersed into preheated gelatin-glycerol solution. A variety of techniques (X-ray diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), differential thermal analysis (DTA), in-vitro swelling-degradation studies and antibacterial tests) were used to characterize the electrospun mats. The results highlight that α-Fe2O3 NPs could be successfully dispersed into the electrospun gelatin nanofibers. The electrospun ferric oxide-gelatin-glycerol nanofibrous mats revealed free beads nanofibers with appropriated swelling-degradation behavior. It was observed that addition of α-Fe2O3 NPs enhanced the antibacterial activity of electrospun mats against positive and negative bacteria. |
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