| 阿苯达唑和奥芬达唑对猪囊尾蚴延胡索酸还原酶的抑制作用 |
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| 引用本文： | 高继国,高学军,郝艳红.阿苯达唑和奥芬达唑对猪囊尾蚴延胡索酸还原酶的抑制作用[J].黑龙江畜牧兽医,2002,1(8):8-9. |
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| 作者姓名： | 高继国 高学军 郝艳红 |
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| 作者单位： | 东北农业大学生命科学,黑龙江哈尔滨150030 |
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| 基金项目： | 黑龙江省自然科学基金项目 |
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| 摘 要： | 研究测定了阿苯达唑和奥芬达唑对猪囊尾蚴组织匀浆延胡索酸还原酶活性的抑制作用。结果表明两种经物均能抑制延胡索酸还原酶活性，提示苯并咪唑氨基甲酸酯药物的作用机理可能是非竞争性抑制延胡索酸还原酶复合体，从而导致虫体因能量耗竭而死亡。
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| 关 键 词： | 阿苯达唑 奥芬达唑 猪囊尾蚴 延胡索酸还原酶 抑制作用 |
| 文章编号： | 1004-7034(2002)08-0008-02 |
| 修稿时间： | 2002年6月20日 |
Inhabition of albendazole and oxfendazole on the activity of fumaric reductase in Cysticercus cellulosae |
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| GAO Ji-guo,GAO Xue-jun,HAO-Yan-hong.Inhabition of albendazole and oxfendazole on the activity of fumaric reductase in Cysticercus cellulosae[J].Heilongjiang Animal Science And veterinary Medicine,2002,1(8):8-9. |
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| Authors: | GAO Ji-guo GAO Xue-jun HAO-Yan-hong |
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| Abstract: | The activity of fumaric reductase in Cysticercus cellulosae tissue homogenate with albendazole and oxfendazole individually was detected.The results showed that the two kinds of drugs both could inhabite the activity of fumaric reductase.The results indicate that the mechanism of action of benzimidazole carbamate drugs is probably inhabiting the complex of fumaric reductase noncompetently, thus lead to the exhaostion of energy and death. |
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| Keywords: | Albendazole Oxfendazole Cysticercus cellulosae Fumaric reductase |
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