Irrelevance between the induction of anti-Campylobacter humoral response by a bacterin and the lack of protection against homologous challenge in Japanese Jidori chickens |
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Authors: | Okamura Masashi Tominaga Ayumi Ueda Michihiro Ohshima Rumiko Kobayashi Masahide Tsukada Mari Yokoyama Eriko Takehara Kazuaki Deguchi Kazuhiro Honda Takashi Nakamura Masayuki |
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Institution: | Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine, Towada, Aomori, Japan. okamuram@vmas.kitasato-u.ac.jp |
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Abstract: | On-farm vaccination of chickens against Campylobacter jejuni is considered a potentially effective countermeasure to decrease campylobacteriosis via consumption of contaminated chicken meat, but is not yet available. In this study, 2 groups of Jidori chicks were immunized subcutaneously with a formalin-killed C. jejuni with 2 different adjuvants. Other chicks served as the unvaccinated control group. Both vaccines induced high levels of anti-Campylobacter IgG but did not decrease bacterial excretion in cecal droppings and bacterial load in the liver and spleen after oral challenge with 10(5) CFU of the homologous strain. Further study is needed to address the observed irrelevance and to develop a novel effective vaccine against C. jejuni. |
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