Effect of morphine and naloxone on LH response and sexual behavior of rams (Ovis aries) |
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| Institution: | 1. Université de Monastir, Faculté des Sciences de Monastir, Laboratoire des Interfaces et des Matériaux Avancés (LIMA), Bd. de l’environnement, 5019 Monastir, Tunisia;2. Université de Monastir, Institut Supérieur des Sciences Appliquées et de Technologie de Mahdia, Tunisia;3. Université de Monastir, Institut Supérieur des Etudes Technologiques de ksar Hellal, Laboratoire de Génie Textile (LGTex), 5070 Monastir, Tunisia;4. Université de Normandie, Laboratoire Polymères Biopolymères Surfaces, UNIROUEN, INSA Rouen, CNRS, PBS, 76000 Rouen, France;1. Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada,;2. Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK, Canada;3. Zoology Department, Center for Integrative Toxicology, Michigan State University, East Lansing, MI, USA;4. School of Biological Sciences, University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China;5. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, People’s Republic of China;1. Laboratory of Neuroendocrinology of Aging, Centre Hospitalier de l’Université de Montréal, 900 St-Denis Street, R Pavilion, Rm R05.436B-02, Montreal, QC, H2X0A9, Canada;2. Physiology of Reproduction and Behaviour Unit (PRC), University of Tours, INRA Centre of Tours, F-37380, Nouzilly, France;3. Institut Armand-Frappier, INRS, 531 Bld des Prairies, Laval, QC, H7V 1B7, Canada;4. Department of Medicine, University of Montreal, Montreal, QC, H3C 3J7, Canada;5. Institut de cardiologie de Montréal Research Center, Montreal, QC, H4J 1C5, Canada;6. Department of Nutrition, University of Montreal, Montreal, QC, H1T 1C8, Canada;7. Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, G1V 4L3, Canada;1. The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institution of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China;2. Power China Guiyang Engineering Corporation Limited, Guiyang, Guizhou 550081, China;3. University of Chinese Academy of Sciences, Beijing 100049, China;4. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, the Chinese Academy of Sciences, Wuhan, Hubei 430072, China;1. UMR 7209 Archéozoologie, archéobotanique: sociétés, pratiques, environnements, Sorbonne Universités, CNRS-MNHN, 55 rue Buffon, 75005 Paris, France;2. National Museum of Romanian History, 12 Calea Victoriei, Sector 3, 030026 Bucharest, Romania;3. UMR 8215 Trajectoires, De la sédentarisation à l’Etat, Maison de l’Archéologie et de l’Ethnologie, 21 allée de l’Université, 92023 Nanterre, France;4. Institute of Archaeology, Research Centre for the Humanities, Hungarian Academy of Sciences, 1014 Budapest, Úri 49, Hungary;5. CAS, Geo Instituut, KU Leuven, Celestijnenlaan 200E, Box 2408, 3001 Leuven, Belgium;6. Department of Biology, University of Leuven, C. Deberiotstraat 32, 3000 Leuven, Belgium;7. Römisch-Germanische Kommission des Deutschen Archäologischen Instituts, 60325 Frankfurt, Germany;8. Institut für Ur-und Frühgeschichte und Vorderasiatische Archäologie, Universität Heidelberg, 69117 Heidelberg, Germany |
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| Abstract: | Effects of the opiate agonist, morphine, and antagonist, naloxone, on LH release, courtship behavior and ejaculation frequency of mature, sexually active or sexually inactive rams were investigated. Plasma LH concentrations were monitored from blood samples collected every 15 min for 10 hr (0800 to 1800 hr) from eight rams that were isolated from or in contact with estrous females. Plasma LH concentration was higher (P<.05) in sexually active rams exposed to receptive females compared with hormone concentration of rams isolated from ewes. Intravenous infusion of morphine sulphate (1 mg/kg) into rams 4 and 6 hr after exposure to ewes reduced (P<.05) plasma LH concentration as compared to rams given saline. Morphine did not affect (P>.05) courtship behavior (investigatory sniff, mount attempt, foreleg kick, flehmen, vocalization) but diminished (P<.05) number of ejaculations. In another trial, LH concentrations were higher (P<.05) in seven sexually active rams given naloxone iv or when given to three rams through an intracerebroventricular cannula (icv) as compared to LH response of sexually inactive rams. LH did not differ (P>.05) in seven sexually inactive rams before or after administration of naloxone. Investigatory sniffs by sexually active rams were increased (P<.03) after treatment with the opiate antagonist. Four of the seven sexually active rams had more ejaculations after naloxone compared with the pretreatment period, but mean ejaculation frequency after treatment did not differ (P=.31). Naloxone did not stimulate courtship behavior of sexually inactive males. These data suggest that the effect of opiates on sexual behavior and LH secretion depends upon the inherent level of sexual activity among rams. |
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