Dermal pharmacokinetics of the insecticide furathiocarb in rats |
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Authors: | Liu Kwang-Hyeon Sung Ha-Jung Lee Hae-Keun Song Byung-Hun Ihm Yang-Bin Kim Kyun Lee Hye-Suk Kim Jeong-Han |
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Institution: | School of Agricultural Biotechnology, Seoul National University, Seodundong 103, Suwon, Kyungi 441-744, Korea. |
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Abstract: | The pharmacokinetics of furathiocarb were studied in vivo in male Sprague-Dawley rats following dermal treatment. HPLC and post-column derivatization were used for the analysis of furathiocarb and its metabolites (carbofuran, 3-hydroxycarbofuran and 3-ketocarbofuran). Carbofuran and 3-hydroxycarbofuran were detected in plasma and urine rather than furathiocarb. 3-Ketocarbofuran, another potential metabolite, was not observed in any sample. The concentration of carbofuran was higher than that of 3-hydroxycarbofuran in plasma, but the reverse was the case in urine. The corresponding area under the plasma concentration-time curve, Tmax, and Cmax values of carbofuran and 3-hydroxycarbofuran for 1500 mg kg-1 doses were 2.4-8.0 mg equiv hml-1, 12 h and 0.1-0.4 mg equiv ml-1, respectively. T1/2 was calculated only for 3-hydroxycarbofuran (28 h). Two metabolites were excreted in a dose-dependent manner without saturation. |
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Keywords: | furathiocarb carbofuran 3‐hydroxycarbofuran pharmacokinetics rat skin |
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