| 气腹压力对裸鼠卵巢癌生长的影响 |
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| 引用本文： | 张团英,陈旭,张凤兰,严兆华,李元军,黄美雯,廖靖. 气腹压力对裸鼠卵巢癌生长的影响[J]. 湛江医学院学报, 2010, 0(6): 615-616,620 |
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| 作者姓名： | 张团英 陈旭 张凤兰 严兆华 李元军 黄美雯 廖靖 |
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| 作者单位： | [1]广东医学院附属医院妇产科,广东湛江524001 [2]上海第二军医大学长征医院妇产科,上海200003 |
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| 基金项目： | 广东省科技计划资助项目（No.2007B031302002） |
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| 摘 要： | 目的观察不同气腹压力对恶性肿瘤生长的影响。方法 45只裸鼠腹腔内种植人卵巢癌瘤块,成模后随机分为3组：无气腹组、低气腹组（5mmHg）、高气腹组（10mmHg）,每组15只,模拟不同CO2气腹压力环境,时间为1h。术后4周开腹检查肿瘤生长平均质量,评价不同气腹压力对肿瘤生长的影响。结果高气腹组的肿瘤平均质量为（3245.3±72.2）mg,明显大于无气腹组的（1830.7±69.4）mg及低气腹组的（2362.4±71.3）mg,差异有统计学意义（P〈0.01）。结论气腹压力增高可促进肿瘤生长,可能增加腹腔镜手术后肿瘤生长和种植转移机会。
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| 关 键 词： | 腹腔镜检查 气腹 恶性肿瘤 生长 转移 |
Effect of pneumoperitoneum pressure on ovarian cancer growth in nude rats |
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| Affiliation: | ZHANG Tuan-ying, CHEN Xu, ZHANG Feng-lan, YAN Zhao-hua, LI Yuan-jun, HUANG Mei-wen, LIANG Jing (1. Department of Gynecology and Obstetrics, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China) |
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| Abstract: | Objective To observe the effect of different pneumoperitoneum pressures on malignant tumor growth in nude rats. Methods Forty-five nude rats were implanted intraperitoneally by human ovarian cancer tissue. The animal models were randomly divided into null, low and high pressure groups, and each were treated with 0, 5 and 10 mmHg of CO2 pneumoperitoneum for 1 h. Tumor weight was measured 4 weeks after intervention. Results The tumor weight was （3245.3±72.2） mg, （2362.4±71.3） mg, and （1830.7±69.4） mg in high, low and null pressure groups, respectively, and there was a significant difference between them （P0.01）. Conclusion The increase of pneumoperitoneum pressure can enhance the tumor growth, suggestive of high risk of tumor growth and implantation metastasis after laparoscopic operation. |
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| Keywords: | laparoscopy pneumoperitoneum malignant tumor growth metastasis |
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