Cespitulones A and B,Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata |
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| Authors: | Yu-Chi Lin Shih-Sheng Wang Chung-Hsiung Chen Yao-Haur Kuo Ya-Ching Shen |
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| Affiliation: | 1.School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan; E-Mails: (Y.-C.L.); (C.-H.C.);2.Department of Life Sciences, National Cheng Kung University, No. 1 University Road, Tainan 701, Taiwan;3.Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; E-Mail: ;4.Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan; E-Mail: |
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| Abstract: | Two novel diterpenoids, cespitulones A (1) and B (2), were isolated from extracts of the soft coral Cespitularia taeniata. Both compounds possess an unprecedented bicyclo [10.3.1] ring system with C-C bond connections between C-10 and C-20, and between C-20 and C-11. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 1 exhibited significant cytotoxicity against human medulloblastoma and colon adenocarcinoma cancer cells. |
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| Keywords: | Cespitularia taeniata diterpenoid cespitulone cytotoxicity |
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