Violapyrones H and I,New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci |
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| Authors: | Hee Jae Shin Hwa-Sun Lee Jong Seok Lee Junho Shin Min Ah Lee Hyi-Seung Lee Yeon-Ju Lee Jieun Yun Jong Soon Kang |
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| Affiliation: | 1.Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea; E-Mails: (H.-S.L.); (J.S.L.); (J.S.); (M.A.L.); (H.-S.L.); (Y.-J.L.);2.Department of Marine Biotechnology, University of Science and Technology, 217 Gajungro, Daejeon 305-350, Korea;3.Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongwon 323-883, Korea; E-Mails: (J.Y.); (J.S.K.) |
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| Abstract: | Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (1–4) exhibited cytotoxicity against 10 human cancer cell lines with GI50 values of 1.10–26.12 μg/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C. |
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| Keywords: | Streptomyces sp., violapyrones, anti-cancer activity, α -pyrones, starfish |
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