Calcium entry blockers inhibit contractures induced by the molluscicide Frescon in Lymnaea stagnalis smooth and cross-striated muscles |
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Authors: | B.L. Brezden D.R. Gardner |
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Affiliation: | Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada |
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Abstract: | The molluscicide Frescon induces irreversible contracture in smooth and cross-striated muscles of the freshwater snail Lymnaea stagnalis. This contracture can be inhibited or reversed by elevated Mg2+ and reduced Ca2+ concentrations, by the heavy metals Ni2+, Co2+, and Mn2+, by the rare earth La3+, and by the calcium channel blocker D-600. The removal of extracellular Ca2+ also prevents the expression of Frescon action. These results are consistent with the hypothesis that Frescon causes an increase in the Ca2+ permeability of the sarcolemma. |
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