昆虫谷胱甘肽－S－转移酶的基因组学研究及其介导的抗药性

谷胱甘肽－S－转移酶（glutathione S-transferases，GSTs）是一类广泛分布于生物体的重要解毒酶系。它的功能广泛，主要包括催化还原型谷胱甘肽与有毒亲电子化合物扼合，以增加毒性物质的水溶性而排除体外；作为过氧化物酶，对脂质过氧化产物进行解毒，从而降低氧化应激损伤；及以隔离机制被动结合杀虫剂等。昆虫GSTs主要分为6个已知的基因家族，其中Delta和Epsilon为昆虫特异的家族，已鉴定的抗药性相关基因则主要分属于这两个家族。本文主要对昆虫GSTs的比较基因组学及在杀虫剂抗性中的作用等相关研究进展进行综述。

Genomic Studies of Glutathione S-Transferase in Insects and Insecticide Resistance Mediated by It

Glutathione S-transferase is an important detoxification isoenzyme, which is wtdely distributed in living organisms. The multifunctional GSTs can catalyze nucleophilic attack by reduced glutathione （GSH） on electrophilic compounds. It also has peroxidase activity, which can detoxify lipid hydroperoxidesand decrease oxidative injury. In addition,GSTs offer a passive protection towards insecticides by binding to their molecule in a sequestering mechanism. Insect GSTs contain six major classes. Delta and Epsilon are insect--specific classes, which are mainly related to insecticide resistance. The present paper presents a review of the progress in the researches concerning comparative genomic analysis of insect GSTs and their functions in insecticide resistance.