石榴皮鞣质的长期毒性研究 |
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引用本文: | 杨林,周本宏. 石榴皮鞣质的长期毒性研究[J]. 安徽农业科学, 2009, 37(18): 8529-8530 |
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作者姓名: | 杨林 周本宏 |
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作者单位: | 1. 三峡大学护理学院,湖北宜昌,443000 2. 武汉大学人民医院,湖北武汉,430060 |
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摘 要: | [目的]观察石榴皮鞣质长期给药对大鼠产生的毒性反应。[方法]将80只供试大鼠随机分为4组,每组分别以0.3,0.9,1.5g/kg石榴皮鞣质连续对试验大鼠灌胃给药4周并设空白对照,末次给药24h后每组活杀一半大鼠,另一半停药后继续观察2周,分别测试大鼠体重、血液学、血液生化学、脏器系数及病理组织学变化。[结果]石榴皮鞣质3个剂量组与对照组比较无明显的毒性。[结论]石榴皮鞣质在上述剂量下连续服用4周是安全的。
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关 键 词: | 石榴皮 鞣质 长期毒性 |
Study on the Long-term Toxicity of Tannin in Punica granatum L. |
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Affiliation: | YANG Lin et al ( College of Nursing ,Three Gorges University, Yichang, Hubei 443000) |
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Abstract: | [Objective] The research aimed to study the long-term toxicity of tannin in Punica granatum L.on rats.[Method] 80 rats were randomly divided into 4 groups,each group were given tannin in dose of 1.5、0.9 or 0.3 mg/kg for 4 weeks.Half of animals were killed immediately after last dose 24 h and another half of rats were observed for 2 weeks after medicine withdraw,and blank control group was designed.Body weight,hematology blood biochemistry,organ index and histopathological changes were examined.[Result] The results showed that there was no obvious toxicity compared with control.[Conclusion] Tannin in Punica granatum L.should be safe in its clinical use with the recommended dosage. |
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Keywords: | Punica granatum L. Tannin Long-term toxicity |
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