小鼠子宫壁内自然杀伤细胞和T细胞亚群与自发性胚胎丢失相关性研究

免疫组化研究显示，小鼠妊娠早期子宫壁内CD57^ 细胞数量由孕0天时16.3增至孕2天时62.3,孕4天时已下降，孕6天时降至9.7，而发生胚胎丢失的个体孕6天和孕8天时细胞数量均维持较多，约是孕0天时的4倍。CD4^ 细胞在妊娠后数量由孕0天时29.7增至孕4天时65.6，孕6天时降至7.2，发生胚胎丢失的个体孕6天及孕8天时数量均较多，约为孕0天时的6倍。CD8^ 细胞妊娠后数量由孕0天时39.8增至孕2天时185.0，孕4天时已下降，孕6天时降至3.6，而发生胚胎丢失的个体孕6天和孕8天时细胞数量均维持较多，约是孕0天时的3倍。研究结果提示小鼠妊娠早期子宫壁内CD57^ 细胞、CD4^ 细胞和CD8^ 细胞数量在胚胎着床前均出现先增后减的波动，早期胚胎丢失与孕6天及孕8天时子宫壁内所含大量CD57^ 细胞、CD4^ 细胞和CD8^ 细胞之间存在相关。

Quantitative Fluctuation of NK Cells and T Lymphocyte Subgroups in Early Pregnant Mouse Uterus and Their Correlations to Abortion

Immunohistochemically studies showed that the quantity of CD 57 cells in early pregnant mouse uterus increased from 16.3 at day 0 to 62.3 at day 2,decreased to 33.0 at day 4 and 9.7 at day 6 after pregnancy. It was about 4 times higher at day 6 and day 8 in abortive uterus than that at day 0 after pregnancy.The quantity of CD 4 cells in early pregnant mouse uterus increased from 29.7 at day 0 to 65.6 at day 4 and decreased to 7.2 at day 6 after pregnancy. It maintained about 6 times higher at day 6 and day8 in abortive uterus than that at day 0 after pregnancy. The quantity of CD 8 cells in early pregnant uterus increased from 39.8 at day 0 to 185.0 at day 2 and decreased to 13.0 at day 4 and 3.6 at day 6 after pregnancy. It was about 6 times higher at day 6 and day 8 in aborting uterus than that at day 0 after pregnancy. The results suggest that the quantity of CD 57 cells, CD 4 cells and CD 4 cells in the early pregnant mouse uteri fluctuate respectively and early abortions have to do with the high quantity of CD 57 cells, CD 4 cells in uteri at day 6 and day 8 after pregnancy.