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The genome of the sea urchin Strongylocentrotus purpuratus |
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| Authors: | Sea Urchin Genome Sequencing Consortium Sodergren Erica Weinstock George M Davidson Eric H Cameron R Andrew Gibbs Richard A Angerer Robert C Angerer Lynne M Arnone Maria Ina Burgess David R Burke Robert D Coffman James A Dean Michael Elphick Maurice R Ettensohn Charles A Foltz Kathy R Hamdoun Amro Hynes Richard O Klein William H Marzluff William McClay David R Morris Robert L Mushegian Arcady Rast Jonathan P Smith L Courtney Thorndyke Michael C Vacquier Victor D Wessel Gary M Wray Greg Zhang Lan Elsik Christine G Ermolaeva Olga Hlavina Wratko Hofmann Gretchen Kitts Paul Landrum Melissa J |
| Abstract: | We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes. |
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