Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration in Hanwoo,Korean native cattle

Pharmacokinetic (PK) parameters of marbofloxacin (MRFX) in Korean cattle, Hanwoo, weredetermined following its intravenous (i.v.) or intramuscular (i.m.) administration at adose of 2 mg/kg. Area under the curve (AUC_{0–24 hr}), half-life (t_1/2)and total body clearance (CL_B) of i.v. MRFX were 6.87hr∙µg/ml, 2.44 hr and 0.29 l/kg∙hr,respectively, and the corresponding values for i.m. administration of MRFX were 5.07hr∙µg/ml, 2.44 hr and 0.39 l/kg∙hr.The suggested optimal doses of MRFX in Hanwoo cattle, calculated by integration of PK dataobtained in the present study and previously reported minimum inhibitory concentration(MIC) for MRFX against susceptible (MIC ≤1 µg/ml) andintermediate (MIC ≤2 µg/ml) pathogenic bacteria, were2.1 and 4.2 mg/kg/day by i.v. route and 3.9 and 7.8 mg/kg/day by i.m. route.