不同剂型氟苯尼考对实验性鸡大肠杆菌病的疗效

以人工诱发鸡大肠杆菌病为模型,研究了不同剂型氟苯尼考的疗效。15日龄AA鸡随机分组,除健康对照组外,各组动物均肌肉注射大肠杆菌(O78)肉汤培养物诱发大肠杆菌病。氟苯尼考预混剂(100 mg/kg拌料)、可溶性粉(100 mg/L饮水)和注射剂(20mg/kg肌注)分别于攻毒前24 h、攻毒同时及攻毒后4 h给药。主要以各组动物存活数为标准评价疗效。结果表明,氟苯尼考预混剂、可溶性粉和注射剂对鸡大肠杆菌病的有效率分别为70%、90%和93.3%,而感染对照组的死亡率为73.3%,试验各组之间鸡的增重差异不显著。试验结果提示氟苯尼考饮水剂和注射剂可有效控制重症大肠杆菌病,预混剂可作为预防用药或用于治疗早期轻度感染。

Eefficacy of Different Preparations of Florfenicol on Experimental Colibacillosis in Chicken

To investigate the therapeutic effects of florfenicol,different dosage forms of florfenicol were prepared and used in experimental colibacillosis in chicken.Florfenicol premix was added to the feed at 100mg/kg 24h before injection of E coli suspension,and the soluble florfenicol powder was administered via drinking water at 100mg/L just after the challenge infection.These two preparations were applied for five successive days.Florfenicol injection was administered intramuscularly at a single dose of 20mg/kg 4h after injection of E.coli suspension.The protected animals of different groups were countered for evaluation of efficacy.The results showed that the effective rates of florfenicol premix,soluble florfenicol powder and florfenicol injection for colibacillosis in chicken were 70%,90% and 93.3% respectively,while the mortality of the control group was 73.3%.The weight gains were not significantly different among groups.The results above suggested that the soluble florfenicol powder and florfenicol injection might be superior to florfenicol premix in controlling the severe infection with E coli in chicken.