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The stereoisomerism of second generation anticoagulant rodenticides: a way to improve this class of molecules to meet the requirements of society?
Authors:Virginie Lattard  Etienne Benoit
Abstract:Second generation anticoagulant rodenticides (SGAR) are generally highly efficient for rodent management even towards warfarin‐resistant rodents. Nevertheless, because of their long tissue‐persistence, they are very associated with non‐target exposure of wildlife and have been identified as ‘Candidates for Substitution’ by the European Union's competent authority. A promising way to reduce ecotoxicity issues associated to SGAR could be the improvement of SGAR based on their stereoisomery, and due to this improvement, positioning about SGAR might be reconsidered. © 2018 Society of Chemical Industry
Keywords:second generation anticoagulant  stereoisomery  vitamin K epoxide reductase  persistence  resistance  ecotoxicity
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