Half-Body Radiotherapy |
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| Authors: | Elizabeth J. Laing DVM DVSc Peter J. Fitzpatrick MB BS FRCP FRCR AIan M. Norris DVM AIlen Mosseri MSc Walter D. Rider MB FRCP FRCP AIlen G. Binnington DVM MSc Angela Baur BVSc V. E. Valli DVM PhD |
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| Affiliation: | Department of Clinical Studies, Ontario Veterinary College, Guelph, Canada. |
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| Abstract: | Eight healthy mongrel dogs were treated with half-body irradiation (HBI) in a pilot study to evaluate the technique and radiotolerance of different organs. Cranial and caudal half-body fields were established using the 13th thoracic vertebra as the dividing point. Under general anesthesia, either 7 or 8 Gray (Gy) were delivered to one half of the body using opposing radiation portals. The other half of the body was similarly treated 28 days later. The dogs were monitored for 12 months. Significant radiation effects included transient bone marrow suppression and radiation sickness. There were no serious or life-threatening problems, but the 8 Gy group consistently showed more severe clinical signs and histologic changes than the 7 Gy group. Total body irradiation in two fractions of 7 or 8 Gy given 1 month apart appears to be a safe treatment that can be developed for therapy in veterinary oncology. |
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