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Putative drug-related pemphigus foliaceus in four dogs |
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| Authors: | White Stephen D Carlotti Didier N Pin Didier Bonenberger Terri Ihrke Peter J Monet Eric Nishifuji Koji Iwasaki Toshiroh Papich Mark G |
| Institution: | Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA; Cabinet de Dermatologie Vétérinaire, Héliopolis B3, Avenue de Magudas, F-33700 Bordeaux-Mérignac, France; Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, California 95616, USA; Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 85023 USA; Department of Veterinary Internal Medicine, Tokyo University of Agriculture and Technology, Tokyo 183–8509, Japan; Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 USA |
| Abstract: | Four dogs developed cutaneous lesions following the administration of various antibiotics. Histopathology of the lesions was compatible with pemphigus foliaceus, although apoptotic cells suggestive of erythema multiforme were seen in two cases. In two dogs the lesions resolved after 7.5-8.5 months of immune-suppressive treatment. No recurrence was seen during the follow-up period (3 and 4.5 years). The lesions in the other two dogs resolved within 3 weeks to 3 months following discontinuation of the antibiotic. No recurrence of clinical signs occurred during the follow-up period (1 and 4 years, respectively). |
| Keywords: | adverse drug reaction antibiotics dogs pemphigus foliaceus skin lesions |
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