| 醇相二步法合成甘氨酸的研究 |
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| 引用本文： | 钱益斌,杨利民.醇相二步法合成甘氨酸的研究[J].安徽农业科学,2009,37(13):5828-5829. |
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| 作者姓名： | 钱益斌 杨利民 |
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| 作者单位： | 江苏工业学院化学工程系,江苏常州,213164;江苏工业学院化学工程系,江苏常州,213164 |
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| 摘 要： | 对氯乙酸氨解法合成甘氨酸工艺进行了改进和优化。试验分为2步进行，先在氯乙酸的甲醇溶液中通入氨气，反应制取氯乙酸铵；再在氯乙酸铵的甲醇溶液中加入适量催化剂乌洛托品，在适宜条件下通氨反应，得到产品甘氨酸。试验考察了第二步反应中的主要影响因素，优化条件为通氨时间120min，反应温度60℃，n（氯乙酸铵）：n（甲醇）=1：7．5，保温时间为45min。在母液套用条件下，第二步反应的单步收率可达99．35％，经2步合成后甘氨酸收率可达97．72％。
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| 关 键 词： | 甘氨酸 氯乙酸氨解法 母液回用 工艺优化 |
Study on the Synthesis of Glycine by Two-step Reaction Approach in Alcohol Phase |
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| QIAN Yi-bin et al.Study on the Synthesis of Glycine by Two-step Reaction Approach in Alcohol Phase[J].Journal of Anhui Agricultural Sciences,2009,37(13):5828-5829. |
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| Authors: | QIAN Yi-bin |
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| Institution: | QIAN Yi-bin et al (Department of Chemical Engineering,Jiangsu Polytechnic University,Changzhou,Jiangsu 213164) |
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| Abstract: | The synthesis technology of glycin by using ammonolysis method of chloroacetic acid were improved and optimized.Glycin was synthesized through a two-step process.At first,ammonium monochloroacetate was prepared through pumping ammonia gas in methanol liquor of chloroacetic acid.Then appropriate amount of urotropine was added as the catalyst and the product glycin was obtained from through pumping ammonia gas under suitable conditions.The main factors affecting the yield of the second step were investigated.... |
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| Keywords: | Glycine Ammonolysis method of chloroactic acid Mother liquor reclamation Technology optimization |
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