Patterns of nodal metastases,biological behaviour and prognosis of canine mast cell tumours of the pinna: A multi-institutional retrospective study |
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| Authors: | Carmit Chalfon Riccardo Finotello Silvia Sabattini Irina Gramer Joanna Siriol Morris Marina Aralla Emanuela Maria Morello Erica Ferraris Sofia Ramos Gerry Polton Luca Schiavo Jane Dobson Veronica Cola Laura Marconato |
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| Institution: | 1. Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Italy;2. Department of Small Animal Clinical Science, School of Veterinary Science, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, UK;3. Department of Clinical Science and Services, Royal Veterinary College, London, UK;4. Department of Small Animal Clinical Sciences, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK;5. Pronto Soccorso Veterinario Laudenese, Oncology Service, Lodi, Italy;6. Department of Veterinary Sciences, University of Turin, Grugliasco, Italy;7. North Downs Specialist Referrals, Bletchingley, UK;8. Department of Veterinary Medicine, Cambridge Veterinary School, University of Cambridge, Cambridge, UK |
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| Abstract: | Canine cutaneous mast cell tumours (cMCTs) of the pinna have been associated with an aggressive biological behaviour, although data remain scarce. The knowledge acquired over the past years on histologic gradings, and the value of lymph node (LN) staging, may help in better characterizing this anatomical presentation. The first aim was to describe the frequency, location, and histologic appearance of LN metastases in cMCT of the pinna. A second aim was to evaluate prognosis. Medical records of dogs with cMCT of the pinna, that underwent tumour and sentinel (SLN) or regional LN (RLN) excision, were reviewed. The influence of potential prognostic variables on time to progression (TTP) and tumour-specific survival (TSS) was investigated. Thirty-nine dogs were included: 19 (48.7%) had Kiupel high-grade (K-HG) and 20 (51.3%) had low-grade (K-LG) MCTs. Eighteen (46.1%) dogs underwent SLN mapping: the superficial cervical LN was at least one of SLN in 17 (94.4%) cases. Twenty-two (56.4%) dogs had LN metastases; the superficial cervical LN was always involved. On multivariable analysis, only K-HG was associated with increased risk of progression (p = .043) and tumour-related death (p = .021). Median TTP and TSS were 270 and 370 days in K-HG, respectively; these were not reached in dogs with K-LG tumours (p < .01). cMCTs of the pinna are often K-HG and are also associated with a higher frequency of LN metastasis; however, we confirmed the independent prognostic value of histologic grading. A multimodal treatment may lead to favourable long-term outcome. Moreover, the superficial cervical LN is most often the SLN. |
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| Keywords: | dog mastocytoma metastasis nodal outcome pinnal |
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