Predominant autoantibody production by early human B cell precursors |
| |
Authors: | Wardemann Hedda Yurasov Sergey Schaefer Anne Young James W Meffre Eric Nussenzweig Michel C |
| |
Institution: | Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA. |
| |
Abstract: | During B lymphocyte development, antibodies are assembled by random gene segment reassortment to produce a vast number of specificities. A potential disadvantage of this process is that some of the antibodies produced are self-reactive. We determined the prevalence of self-reactive antibody formation and its regulation in human B cells. A majority (55 to 75%) of all antibodies expressed by early immature B cells displayed self-reactivity, including polyreactive and anti-nuclear specificities. Most of these autoantibodies were removed from the population at two discrete checkpoints during B cell development. Inefficient checkpoint regulation would lead to substantial increases in circulating autoantibodies. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|